Journal article

Dynamic kinetic asymmetric domino oxa-michael/carbocyclization by combination of transition-metal and amine catalysis: Catalytic enantioselective synthesis of dihydrofurans

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Author list: Còrdova, Armando

Publication year: 2010

Start page: 13930

End page: 13934

Number of pages: 5

ISSN: 0947-6539

DOI: http://dx.doi.org/10.1002/chem.201001992

View additional information: View in Web of Science


Abstract

Into the pot: A one-pot highly chemo- and enantioselective catalytic domino oxa-Michael/carbocyclization between a,ß-unsaturated aldehydes and propargylic alcohols is presented. This dynamic kinetic transformation requires a combination of transition-metal and amine catalysis to afford functionalized dihydrofurans in good to high yields and up to 99.5:0.5 e.r.


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