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Highly Diastereo- and Enantioselective Cascade Synthesis of Bicyclic Lactams in One-Pot

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Author list: Córdova, Armando

Publication year: 2018

Start page: 1158

End page: 1164

Number of pages: 7

ISSN: 1434-193X

DOI: http://dx.doi.org/10.1002/ejoc.201701789

View additional information: View in Web of Science


Abstract

A versatile and highly stereoselective synthetic route to functionalized bi- and tricyclic lactams (up to > 20:1 dr and 99 % ee) in one pot from simple starting materials (allylic alcohols, enals, diamines and amino alcohols) using cascade transformations promoted by chiral amine/Brønsted or metal/chiral amine/Brønsted relay catalysis is disclosed. Here molecular oxygen is employed as the terminal oxidant for the latter relay catalysis approach.


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