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Highly Diastereo- and Enantioselective Cascade Synthesis of Bicyclic Lactams in One-Pot
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Author list: Córdova, Armando
Publication year: 2018
Start page: 1158
End page: 1164
Number of pages: 7
ISSN: 1434-193X
DOI: http://dx.doi.org/10.1002/ejoc.201701789
View additional information: View in Web of Science™
Abstract
A versatile and highly stereoselective synthetic route to functionalized bi- and tricyclic lactams (up to > 20:1 dr and 99 % ee) in one pot from simple starting materials (allylic alcohols, enals, diamines and amino alcohols) using cascade transformations promoted by chiral amine/Brønsted or metal/chiral amine/Brønsted relay catalysis is disclosed. Here molecular oxygen is employed as the terminal oxidant for the latter relay catalysis approach.
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