Journal article

Dynamic One-Pot Three-Component Catalytic Asymmetric Transformation by Combination of Hydrogen-Bond-Donating and Amine Catalysts

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Publication Details

Author list: Cordova, Armando

Publication year: 2011

Start page: 7624

End page: 7630

Number of pages: 7

ISSN: 1433-7851

DOI: http://dx.doi.org/10.1002/anie.201101966

View additional information: View in Web of Science


Abstract

In control: The first dynamic one-pot three-component asymmetric transformation between aldehydes, protected a-cyanoglycine esters, and enals catalyzed by a combination of a simple hydrogen-bond-donating catalyst and a chiral amine catalyst is disclosed. Polysubstituted proline derivatives, which have a quaternary a stereocenter, were synthesized with high endo-, diastereo-, and enantioselectivities (93-99 ee). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


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