Journal article

Efficient and highly enantioselective aerobic oxidation-michael- carbocyclization cascade transformations by integrated Pd(0)-CPG nanoparticle/chiral amine relay catalysis

Authors/Editors

No matching items found.



Research Areas

No matching items found.


Publication Details

Author list: ZHANG R, CÓRDOVA A, Afewerki S, ZHANG R, CÓRDOVA A

Publication year: 2014

Start page: 1303

End page: 1310

Number of pages: 8

ISSN: 0039-7881

DOI: http://dx.doi.org/10.1055/s-0033-1340883

View additional information: View in Web of Science


Abstract

A series of highly diastereo- and enantioselective aerobic oxidation-Michael-carbocyclization cascade transformations by integrated heterogeneous Pd(0)-CPG nanoparticle/chiral amine relay catalysis are disclosed. The heterogeneous Pd(0)-CPG nanoparticle catalysts were efficient for both the sequential aerobic oxidation and dynamic kinetic asymmetric Michael- carbocyclization transformations, resulting in 1) oxidation of a variety of allylic alcohols to enals and 2) formation of cyclopentenes containing an all-carbon quaternary stereocenter in good to high yields with up to 20:1 dr and 99.5:0.5 er. © Georg Thieme Verlag Stuttgart.New York.


Projects

No matching items found.


Keywords

No matching items found.


Documents

No matching items found.