Gram bean extract-mediated synthesis of Fe3O4 nanoparticles for tuning the magneto-structural properties that influence the hyperthermia performance


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Publication Details

Author list: Phadatare, Manisha R.

Publication year: 2019

Start page: 357

End page: 368

Number of pages: 12

ISSN: 1876-1070

DOI: http://dx.doi.org/10.1016/j.jtice.2018.07.039

View additional information: View in Web of Science


A green synthesis of biocompatible magnetite (Fe3O4) nanoparticles (MNPs) using a combination of urea (U) and gram-bean extract (GBE, Cicer arietinum L.) is reported. The particle size of similar to 13 nm and highly stable magnetite phase is observed for GBE-U mediated MNPs. On the other hand, the MNPs synthesized using either U or GBE shows larger particle size and uneven size distribution. Interestingly, the sample with particle size similar to 13 nm shows optimum heat generation capacity (measured in specific absorption rate, i.e., SAR) near to the therapeutic temperature (43 degrees C) with least-variance. To investigate the influence of various factors such as variation in MNPs weight concentration (W-t), applied alternating magnetic field (AMF), saturation magnetization (M-s), magnetization rate (R-m), etc. on SAR, a multiple linear regression model (MLRM) is used. The study reveals a positive correlation of SAR with R-m, and AMF values while the negative correlation with M-s and W-t. Ultimately, the present green synthesis is the affordable approach for preparing stable and tiny MNPs. Moreover, MLRM is found to be a useful theoretical tool for understanding the influence of MNPs on hyperthermia performance.


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