Journal article
Catalytic Enantioselective Synthesis of Bicyclic Lactam N,S-Acetals in One Pot by Cascade Transformations
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Författarlista: ZHANG K, ZHANG K, ZHANG K, DEIANA L, DEIANA L, CÓRDOVA A
Publikationsår: 2019
Startsida: 4649
End page: 4657
Antal sidor: 9
ISSN: 1434-193X
DOI: http://dx.doi.org/10.1002/ejoc.201900923
Visa ytterligare informaiton: View in Web of Science™
Sammanfattning
A versatile strategy for the enantioselective synthesis of bicyclic lactam N,S-acetals by one-pot cascade transformations is disclosed. The transformation of readily available substrates is promoted by chiral amines and creates bicyclic or tricyclic lactam N,S-acetals with high chemo- and stereoselectivity (up to > 99.5:0.5 dr and > 99 % ee) in one-pot operations.
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