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Catalytic Enantioselective Synthesis of Bicyclic Lactam N,S-Acetals in One Pot by Cascade Transformations

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Author list: ZHANG K, ZHANG K, ZHANG K, DEIANA L, DEIANA L, CÓRDOVA A
Publication year: 2019
Start page: 4649
End page: 4657
Number of pages: 9
ISSN: 1434-193X
View additional information: View in Web of Science™

Abstract
A versatile strategy for the enantioselective synthesis of bicyclic lactam N,S-acetals by one-pot cascade transformations is disclosed. The transformation of readily available substrates is promoted by chiral amines and creates bicyclic or tricyclic lactam N,S-acetals with high chemo- and stereoselectivity (up to > 99.5:0.5 dr and > 99 % ee) in one-pot operations.


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