Journal article

Asymmetric Synthesis of Maraviroc (UK-427,857)

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Publication Details

Author list: Cordova, Armando

Publication year: 2010

Start page: 2291

End page: 2298

Number of pages: 8

ISSN: 1615-4150

DOI: http://dx.doi.org/10.1002/adsc.201000287

View additional information: View in Web of Science


Abstract

The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral beta-amino aldehyde key fragment is presented. The reactions were performed on a gram-scale and allow for the rapid construction of new Maraviroc analogues.


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